Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement.

@article{Fallarino2004MurinePD,
  title={Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement.},
  author={Francesca Fallarino and Carine Asselin-Paturel and Carmine Vacca and Roberta Bianchi and Stefania Gizzi and Maria Cristina Fioretti and Giorgio Trinchieri and Ursula Grohmann and Paolo Puccetti},
  journal={Journal of immunology},
  year={2004},
  volume={173 6},
  pages={3748-54}
}
In this study, using a soluble CD200-Ig fusion protein, we provide evidence that murine dendritic cells (DCs) possess a functional CD200R, whose engagement results in the reinforcement or appearance of immunosuppressive properties in these cells. In particular, the plasmacytoid subset (CD11c+B220+120G8+) of splenic DCs (pDCs) is induced by CD200-Ig to express the enzyme IDO, which initiates the tolerogenic pathway of tryptophan catabolism. As a result, pDCs are capable of suppressing Ag… CONTINUE READING