Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.

@article{Ni2002MurinePA,
  title={Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander.},
  author={Dan Ni and Timothy L. Madden and Mary Johansen and Edward A. Felix and Dah Hsi Wang Ho and Robert A. Newman},
  journal={Journal of experimental therapeutics & oncology},
  year={2002},
  volume={2 5},
  pages={278-85}
}
Pharmacokinetic studies of [3H]oleandrin, a cardiac glycoside component of Anvirzel, were conducted in mice after either an i.v. dose (40 micrograms/kg) or a p.o. dose (80 micrograms/kg). Oleandrin was rapidly absorbed after oral dosing (Cmax at 20 min) although the elimination half-life was longer (2.3 +/- 0.5 h) than that after i.v. dosing (0.4 +/- 0.1 h). The AUC0-infinity values obtained after i.v. and p.o. dosing were 24.6 +/- 11.1 and 14.4 +/- 4.3 (ng.h/ml), respectively, resulting in an… CONTINUE READING