Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress.

@article{Ishii1996MurinePM,
  title={Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress.},
  author={Tetsuro Ishii and Toru Yanagawa and Tetsuya Kawane and Kanako Yuki and Jun Seita and Hidemi Yoshida and Shiro Bannai},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={226 2},
  pages={456-60}
}
Using differential screening we have cloned a cDNA encoding a novel oxidative stress protein designated A170 from murine peritoneal macrophages. It has a Zn-finger domain, a PEST domain and several potential phosphorylation sites for kinases. Treatments with oxidative stress agents such as diethyl maleate and paraquat increased a 2.0-kilobase A170 mRNA about twofold in the macrophages after 12 hours in culture. However, H2O2 or glucose/glucose oxidase did not increase the level of the A170 mRNA… CONTINUE READING
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