Murine osteoblasts regulate mesenchymal stem cells via WNT and cadherin pathways: mechanism depends on cell-cell contact mode.

@article{Wang2007MurineOR,
  title={Murine osteoblasts regulate mesenchymal stem cells via WNT and cadherin pathways: mechanism depends on cell-cell contact mode.},
  author={Yongzhong Wang and Vladimir Volloch and Mariya A Pindrus and Dominick J Blasioli and Jingsong Chen and David L Kaplan},
  journal={Journal of tissue engineering and regenerative medicine},
  year={2007},
  volume={1 1},
  pages={39-50}
}
Osteoblasts (OSTs) are derived from mesenchymal stem cells (MSCs) and coexist in close proximity with MSCs in bone during development and remodelling. Interactions between these two cell types remain obscure. Through a well-defined co-culture model, the present work demonstrated that OSTs regulate MSCs through the WNT and cadherin pathways. The regulation mechanism depends on the cell-cell contact mode (indirect or direct) between the two cell types. When physically separated (indirect contact… CONTINUE READING