Murine norovirus-1 cell entry is mediated through a non-clathrin-, non-caveolae-, dynamin- and cholesterol-dependent pathway.

@article{Gerondopoulos2010MurineNC,
  title={Murine norovirus-1 cell entry is mediated through a non-clathrin-, non-caveolae-, dynamin- and cholesterol-dependent pathway.},
  author={Andreas Gerondopoulos and Terry Jackson and Paul F. Monaghan and Nicole M Doyle and Lisa Roberts},
  journal={The Journal of general virology},
  year={2010},
  volume={91 Pt 6},
  pages={1428-38}
}
For many viruses, endocytosis and exposure to the low pH within acidic endosomes is essential for infection. It has previously been reported that feline calicivirus uses clathrin-mediated endocytosis for entry into mammalian cells. Here, we report that infection of RAW264.7 macrophages by the closely related murine norovirus-1 (MNV-1) does not require the clathrin pathway, as infection was not inhibited by expression of dominant-negative Eps15 or by knockdown of the adaptin-2 complex. Further… CONTINUE READING