Murine neuroblastoma attenuates dendritic cell cysteine cysteine receptor 7 (CCR7) expression.

@article{Walker2005MurineNA,
  title={Murine neuroblastoma attenuates dendritic cell cysteine cysteine receptor 7 (CCR7) expression.},
  author={Sonya R Walker and Alexander M Aboka and P Daf{\'e} Ogagan and Edward Metz Barksdale},
  journal={Journal of pediatric surgery},
  year={2005},
  volume={40 6},
  pages={983-7}
}
BACKGROUND/PURPOSE Dendritic cell (DC) migration from tumors to T-cell priming sites is critical in developing antitumor cytotoxicity. Cysteine cysteine receptor 7 (CCR7), a promigratory chemokine receptor, regulates DC recruitment to secondary lymphoid organs. Tumors may inhibit CCR7 expression to evade immunodetection. Previous work implicates impaired DC migration as a critical defect in immunity to neuroblastoma (NB). However, the mechanism has yet to be defined. We hypothesize that NB… CONTINUE READING
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