Murine natural monoclonal autoantibodies: a study of their polyspecificities and their affinities.

@article{Ternynck1986MurineNM,
  title={Murine natural monoclonal autoantibodies: a study of their polyspecificities and their affinities.},
  author={Therese Ternynck and Stratis Avrameas},
  journal={Immunological reviews},
  year={1986},
  volume={94},
  pages={99-112}
}
We have demonstrated that natural monoclonal antibodies (NmAbs) prepared from the spleens of either adult or neonatal non-immunized mice are polyspecific, i.e., they react with various self or non-self antigens. In the present study the polyspecificity of several NmAbs is analyzed in terms of dissociation constants (KDs) using a recently published sandwich-type immunoassay (Friguet et al. 1985). We calculated the NmAb KDs for various croos-reacting self (actin, myosin, tubulin, DNA) or non-self… CONTINUE READING

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