Murine monoclonal antibodies to PorA of Neisseria meningitidis show reduced protective activity in vivo against B:15:P1.7,16 subtype variants in an infant rat infection model.

@article{Toropainen2001MurineMA,
  title={Murine monoclonal antibodies to PorA of Neisseria meningitidis show reduced protective activity in vivo against B:15:P1.7,16 subtype variants in an infant rat infection model.},
  author={Maija Toropainen and Leena Saarinen and Peter van der Ley and Betsy Kuipers and Helena M. K{\"a}yhty},
  journal={Microbial pathogenesis},
  year={2001},
  volume={30 3},
  pages={139-48}
}
The major outer membrane protein PorA of Neisseria meningitidis is the target for bactericidal serosubtyping antibodies and is currently considered as a potential vaccine candidate against group B meningococcal disease. Although the minor antigenic variability of the PorA has been increasingly recognized and described, its implication for vaccine design remains unclear. In this study, the protective activity of murine monoclonal PorA specific antibodies against four isogenic meningococcal P1.7… CONTINUE READING
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