Murine models of pulmonary fibrosis.

@article{Moore2008MurineMO,
  title={Murine models of pulmonary fibrosis.},
  author={Bethany B. Moore and Cory M. Hogaboam},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={294 2},
  pages={
          L152-60
        }
}
  • B. MooreC. Hogaboam
  • Published 1 February 2008
  • Biology, Medicine
  • American journal of physiology. Lung cellular and molecular physiology
Human pulmonary fibrosis is characterized by alveolar epithelial cell injury, areas of type II cell hyperplasia, accumulation of fibroblasts and myofibroblasts, and the deposition of extracellular matrix proteins. The result is a progressive loss of normal lung architecture and impairment in gas exchange. Pertinent features of the human disease include temporal heterogeneity of the fibrotic lesions, progressive nature of the disease, development of fibrotic foci, and in some patients, a rapid… 
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