Murine models of polycystic kidney disease: molecular and therapeutic insights.

@article{GuayWoodford2003MurineMO,
  title={Murine models of polycystic kidney disease: molecular and therapeutic insights.},
  author={L. M. Guay-Woodford},
  journal={American journal of physiology. Renal physiology},
  year={2003},
  volume={285 6},
  pages={F1034-49}
}
Numerous murine (mouse and rat) models of polycystic kidney disease (PKD) have been described in which the mutant phenotype results from a spontaneous mutation or engineering via chemical mutagenesis, transgenic technologies, or gene-specific targeting in mouse orthologs of human PKD genes. These murine phenotypes closely resemble human PKD, with common abnormalities observed in tubular epithelia, the interstitial compartment, and the extracellular matrix of cystic kidneys. In both human and… CONTINUE READING