Murine models for antiretroviral therapy.

  title={Murine models for antiretroviral therapy.},
  author={Ruth M. Ruprecht},
  volume={30 Suppl 1},
Rauscher murine leukemia virus (RLV) infection of adult mice results in splenomegaly that is proportional to the virus titer. We have used this model to study the therapy of chronic viremia as well as chemoprophylaxis after viral exposure, both with single agents and with combination therapy. We showed that prompt initiation of effective antiviral therapy after viral exposure can prevent de novo infection. We have also developed a murine neurotropic retrovirus model which allows analysis of… CONTINUE READING