Murine model of neointimal formation and stenosis in vein grafts.

  title={Murine model of neointimal formation and stenosis in vein grafts.},
  author={Brian Cooley},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={24 7},
  • Brian Cooley
  • Published 2004 in
    Arteriosclerosis, thrombosis, and vascular…
OBJECTIVE Previous studies have suggested that neointimal formation, a central cause of vein graft stenosis, has several potential cell sources. It was hypothesized that neointimal cells arise primarily from the cells of the vein graft. METHODS AND RESULTS This study investigated vein graft neointimal cell origins using a model of vein-to-artery cross-transplantation between transgenic Rosa26 mice (constitutive expression of bacterial beta-galactosidase marker gene) and wild-type mice. Vein… CONTINUE READING

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