Murine model of Clostridium difficile infection with aged gnotobiotic C57BL/6 mice and a BI/NAP1 strain.

@article{Pawlowski2010MurineMO,
  title={Murine model of Clostridium difficile infection with aged gnotobiotic C57BL/6 mice and a BI/NAP1 strain.},
  author={Sean W Pawlowski and Giuseppe Calabrese and Glynis L. Kolling and James A Platts-Mills and Raimundo Freire and C AlcantaraWarren and Bindong Liu and Ryan Balfour Sartor and Richard Littleton Guerrant},
  journal={The Journal of infectious diseases},
  year={2010},
  volume={202 11},
  pages={1708-12}
}
The increased incidence and severity of Clostridium difficile infection (CDI) in older adults (age, ≥65 years) corresponds with the emergence of the BI/NAP1 strain, making elucidation of the host immune response extremely important. We therefore infected germ-free C57BL/6 mice aged 7-14 months with a BI/NAP1 strain and monitored the mice for response. Infected mice were moribund 48-72 h after infection and developed gross and histological cecitis and colitis and elevated concentrations of… CONTINUE READING

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