Murine microglial cells produce and respond to interleukin-18.

  title={Murine microglial cells produce and respond to interleukin-18.},
  author={Marco Prinz and U K Hanisch},
  journal={Journal of neurochemistry},
  volume={72 5},
Interleukin (IL)-18 (interferon-gamma-inducing factor or IL-1gamma) belongs structurally to the IL-1 cytokine family and shares biological properties with IL-12. Expression, intracellular signaling, and functional relevance of IL-18 within the CNS are mostly unknown. We show that IL-18 protein is synthesized within mouse brain, preferentially during early postnatal stages, and that microglial cells but not astrocytes are a potential source. IL-18 is produced by cultured microglia on exposure to… CONTINUE READING


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