Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer

@inproceedings{Zervos2016MurineMC,
  title={Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer},
  author={Emmanuel E. Zervos and Steven C Agle and Andrew G. Freistaedter and Gwendolyn J. B. Jones and Rachel L. Roper},
  booktitle={Journal of experimental & clinical cancer research : CR},
  year={2016}
}
BACKGROUND Mesothelin has attracted much interest as a tumor specific antigen; it has been reported to promote tumor development and to be a good target for cancer treatment. Most studies to date have used human mesothelin in immunocompromised mice. Since these models do not allow for study of the natural immune response to mesothelin expressing tumors, we have undertaken the characterization of mouse mesothelin so the effects of this protein can be assessed in immunocompetent mouse strains… CONTINUE READING