Murine mesenchymal stem cells transplanted to the central nervous system of neonatal versus adult mice exhibit distinct engraftment kinetics and express receptors that guide neuronal cell migration.

@article{Phinney2006MurineMS,
  title={Murine mesenchymal stem cells transplanted to the central nervous system of neonatal versus adult mice exhibit distinct engraftment kinetics and express receptors that guide neuronal cell migration.},
  author={Donald G Phinney and Melody C. Baddoo and Maria F. Dutreil and Dina Gaupp and Wen Tzu Lai and Iryna A. Isakova},
  journal={Stem cells and development},
  year={2006},
  volume={15 3},
  pages={437-47}
}
Mesenchymal stem cells (MSCs) have demonstrated efficacy as cellular vectors for treating a variety of nervous system disorders. Nevertheless, few studies have quantified MSC engraftment levels or explored the mechanisms that promote their survival and migration in nervous tissue. In this study, we compared the engraftment kinetics and anatomical distribution of murine, male MSCs injected intracranially into neonatal versus adult female mice using a real-time PCR assay that targets the mouse… CONTINUE READING

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