Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation.

@article{English2008MurineMS,
  title={Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation.},
  author={Karen English and F Barry and Bernard P. Mahon},
  journal={Immunology letters},
  year={2008},
  volume={115 1},
  pages={50-8}
}
Mesenchymal stem cells (MSC) possess a wide range of immunosuppressive functions. Among these is the ability to inhibit CD4+ T cell proliferation. Dendritic cells (DC) play a role in initiating cell-mediated immunity; however, the immunosuppressive influence of MSC on professional antigen presenting cells remains unclear. DC exposed to TNF-alpha and cultured with murine MSC failed to show regular upregulation of maturation markers. Similarly, the presence of MSC abrogated the capacity of… CONTINUE READING

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