Murine matrix metalloproteinase 9 gene. 5'-upstream region contains cis-acting elements for expression in osteoclasts and migrating keratinocytes in transgenic mice.

@article{Munaut1999MurineMM,
  title={Murine matrix metalloproteinase 9 gene. 5'-upstream region contains cis-acting elements for expression in osteoclasts and migrating keratinocytes in transgenic mice.},
  author={Carine Munaut and Tuire Salonurmi and Sirpa Kontusaari and Paula Reponen and Teppei Morita and Jean Michel Foidart and K. Tryggvason},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 9},
  pages={5588-96}
}
Knowledge about the regulation of cell lineage-specific expression of extracellular matrix metalloproteinases is limited. In the present work, the murine matrix metalloproteinase 9 (MMP-9) gene was shown to contain 13 exons, and the 2.8-kilobase pair upstream region was found to contain several common promoter elements including a TATA box-like motif, three GC boxes, four AP-1-like binding sites, an AP-2 site, and three PEA3 consensus sequences that may be important for basic activity of the… CONTINUE READING

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