Murine major histocompatibility complex class-I mutants: molecular analysis and structure-function implications.

@article{Nathenson1986MurineMH,
  title={Murine major histocompatibility complex class-I mutants: molecular analysis and structure-function implications.},
  author={Stanley G. Nathenson and Jan Geliebter and Gertrude M. Pfaffenbach and Richard A. Zeff},
  journal={Annual review of immunology},
  year={1986},
  volume={4},
  pages={471-502}
}
The class-I mutants have provided a model system for understanding the generation of diversity of the genes encoding the histocompatibility molecules K, D, and L, and the relationship of their structure to function. The complex nature of the alterations found in Kb molecules from mutant mice has been documented at the nucleic acid level for eight mutants. The clustered changes in the mutant genes are consistent with the hypothesis that genetic recombination between class-I genes generates the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 72 extracted citations

Major histocompatibility complex genomics and human disease.

Annual review of genomics and human genetics • 2013
View 1 Excerpt

Differential requirement of CD27 costimulatory signaling for naïve versus alloantigen-primed effector/memory CD8+ T cells.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…