Murine lung tumor measurement using respiratory-gated micro-computed tomography.

  title={Murine lung tumor measurement using respiratory-gated micro-computed tomography.},
  author={Dianna D. Cody and Christopher L. Nelson and William M. Bradley and Marie Wislez and Denise M Juroske and Roger E. Price and Xian wan Zhou and Benjamin Nebiyou Bekele and Jonathan M. Kurie},
  journal={Investigative radiology},
  volume={40 5},
OBJECTIVE The authors explored micro-computed tomography (micro-CT) to quantify lung tumor number and volume in a specific genetic mouse model for lung cancer. MATERIALS AND METHODS The authors used K-ras mice, which develop lung adenomas and adenocarcinomas through somatic activation of the K-ras oncogene. Tumor number measured using micro-CT and were compared at necropsy (n = 38 mice). Tumor volume measurement precision (n = 39 mice) and accuracy (multiple tumors from a single mouse) were… CONTINUE READING


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Micro-CT of rodents: state-of-the-art and future perspectives.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics • 2014
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