Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay

Abstract

Frontotemporal dementia (FTD) is the most common neurodegenerative disorder in individuals under age 60 and has no treatment or cure. Because many cases of FTD result from GRN nonsense mutations, an animal model for this type of mutation is highly desirable for understanding pathogenesis and testing therapies. Here, we generated and characterized GrnR493X… (More)
DOI: 10.1073/pnas.1722344115

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