Murine immunoglobulin G subclass responses following immunization with live dengue virus or a recombinant dengue envelope protein.

@article{Smucny1995MurineIG,
  title={Murine immunoglobulin G subclass responses following immunization with live dengue virus or a recombinant dengue envelope protein.},
  author={J J Smucny and Eileen P. Kelly and P O Macarthy and Alan D. King},
  journal={The American journal of tropical medicine and hygiene},
  year={1995},
  volume={53 4},
  pages={432-7}
}
Murine immunoglobulin G (IgG) subclass responses to immunization are restricted to certain subclasses depending on the nature of the immunogen. Immunization with live viruses generally leads to a predominant IgG2a response, which may be the most effective at resisting future challenge due to the unique effector functions of IgG2a. Knowledge of subclass responses following immunization with dengue vaccine candidates may be helpful in determining which candidates are most efficacious. We measured… CONTINUE READING