Murine immune response to the Neisseria meningitidis group C capsular polysaccharide. I. Ontogeny.

@article{Rubinstein1988MurineIR,
  title={Murine immune response to the Neisseria meningitidis group C capsular polysaccharide. I. Ontogeny.},
  author={Leonard J Rubinstein and Kathryn E. Stein},
  journal={Journal of immunology},
  year={1988},
  volume={141 12},
  pages={4352-6}
}
The immune response to polysaccharide Ag develops late in ontogeny and the underlying mechanisms of the infant unresponsiveness are poorly understood. The development of vaccines that will prove efficacious in infants has been hindered by the lack of animal systems suitable for studying immunity to human pathogens. We have examined the BALB/c murine response to the capsular polysaccharide of Neisseria meningitidis group C (MCPS), a homopolymer of alpha(2----9) sialic acid, as a model system for… CONTINUE READING

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