Corpus ID: 666693

Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest.

@article{Leist1994MurineHA,
  title={Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest.},
  author={M. Leist and F. Gantner and I. Bohlinger and P. Germann and G. Tiegs and A. Wendel},
  journal={Journal of immunology},
  year={1994},
  volume={153 4},
  pages={
          1778-88
        }
}
Freshly isolated mouse hepatocytes were essentially insensitive to TNF-alpha cytotoxicity. However, TNF-alpha induced a concentration-dependent cell death in hepatocytes that had been pretreated with the transcriptional inhibitors actinomycin D (ActD), D-galactosamine, or alpha-amanitin. Unlike RNA synthesis inhibition, a translational block in the presence of cycloheximide (CHX) or puromycin did not sensitive hepatocytes to TNF. On the contrary, these agents prevented hepatocytotoxicity… Expand
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