Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice.

@article{Albuquerque2006MurineHV,
  title={Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice.},
  author={Nadine De Albuquerque and Ehtesham Baig and Xuezhong Ma and Jianhua Zhang and William Peng He and Andrea Rowe and Marlena V Habal and Mingfeng Liu and Itay Shalev and Gregory P Downey and Reginald M Gorczynski and Jagdish W Butany and Julian Leibowitz and Susan R Weiss and Ian D. McGilvray and Melville J Phillips and Eleanor N Fish and Gary A. Levy},
  journal={Journal of virology},
  year={2006},
  volume={80 21},
  pages={10382-94}
}
Severe acute respiratory syndrome (SARS) is a life-threatening infectious disease which has been difficult to study and treat because of the lack of a readily available animal model. Intranasal infection of A/J mice with the coronavirus murine hepatitis virus strain 1 (MHV-1) produced pulmonary pathological features of SARS. All MHV-1-infected A/J mice developed progressive interstitial pneumonitis, including dense macrophage infiltrates, giant cells, and hyaline membranes, resulting in death… CONTINUE READING
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