Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism.

@article{Schildberg2011MurineHS,
  title={Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism.},
  author={Frank A Schildberg and Alexandra Wojtalla and S{\"o}ren Volker Siegmund and Elmar Endl and Linda Diehl and Zeinab F. Abdullah and Christian Kurts and Percy A Knolle},
  journal={Hepatology},
  year={2011},
  volume={54 1},
  pages={262-72}
}
UNLABELLED The liver has a role in T cell tolerance induction, which is mainly achieved through the functions of tolerogenic hepatic antigen-presenting cells (APCs) and regulatory T cells. Hepatic stellate cells (HSCs) are known to have various immune functions, which range from immunogenic antigen presentation to the induction of T cell apoptosis. Here we report a novel role for stellate cells in vetoing the priming of naive CD8 T cells. Murine and human HSCs and stromal cells (but not… CONTINUE READING

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