Murine hematopoietic stem cells and multipotent progenitors express truncated intracellular form of c-kit receptor.

@article{Zayas2008MurineHS,
  title={Murine hematopoietic stem cells and multipotent progenitors express truncated intracellular form of c-kit receptor.},
  author={Jennifer Zayas and Danislav S. Spassov and Ronald G Nachtman and Roland Jurecic},
  journal={Stem cells and development},
  year={2008},
  volume={17 2},
  pages={343-53}
}
The c-kit receptor plays a vital role in self-renewal and differentiation of hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs). We have discovered that besides c-kit, the murine multipotent HSC/MPP-like cell line EML expresses the transcript and protein for a truncated intracellular form of c-kit receptor, called tr-kit. Notably, the tr-kit transcript and protein levels were down-regulated during cytokine-induced differentiation of the HSC/MPP-like cell line EML into… CONTINUE READING

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