Murine guanylate cyclase C regulates colonic injury and inflammation.

  title={Murine guanylate cyclase C regulates colonic injury and inflammation.},
  author={Kris A. Steinbrecher and Eleana M Harmel-Laws and Monica P. Garin-Laflam and Elizabeth A Mann and Lucas D. Bezerra and Simon P Hogan and Mitchell B Cohen},
  journal={Journal of immunology},
  volume={186 12},
Guanylate cyclase C (GUCY2C or GC-C) and its ligands, guanylin (GUCA2A or Gn) and uroguanylin (GUCA2B or Ugn), are expressed in intestinal epithelial cells and regulate ion secretion, intestinal barrier function, and epithelial monolayer homeostasis via cGMP-dependent signaling pathways. The aim of this study was to determine whether GC-C and its ligands direct the course of intestinal inflammation. In this article, we show that dextran sodium sulfate (DSS)-induced clinical disease and… CONTINUE READING
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