Murine gammaherpesvirus-68 infection alters self-antigen presentation and type 1 diabetes onset in NOD mice.

@article{Smith2007MurineGI,
  title={Murine gammaherpesvirus-68 infection alters self-antigen presentation and type 1 diabetes onset in NOD mice.},
  author={Katherine A. Smith and Stacey Efstathiou and Anne Cooke},
  journal={Journal of immunology},
  year={2007},
  volume={179 11},
  pages={7325-33}
}
Recent research in line with the "hygiene hypothesis" has implicated virus infection in the delay or prevention of autoimmunity in murine models of type 1 diabetes such as the NOD mouse. We found that intraperitoneal or intranasal infection of NOD mice with the murine gammaherpesvirus-68 (MHV-68) significantly delayed diabetes onset in an age-dependent manner. The acute phase following intraperitoneal infection was associated with significantly reduced trafficking of autoreactive BDC2.5NOD CD4… CONTINUE READING

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