Murine gammaherpesvirus-68 expands, but does not activate, CD11b+ gr-1+ splenocytes in vivo

@inproceedings{Nelson2011MurineGE,
  title={Murine gammaherpesvirus-68 expands, but does not activate, CD11b+ gr-1+ splenocytes in vivo},
  author={Daniel A. Nelson and Vinita S. Chauhan and Melanie D Tolbert and Kenneth L. Bost},
  booktitle={Journal of Inflammation},
  year={2011}
}
Murine gammaherpesvirus 68 (HV-68) is an efficient pathogen, capable of infecting and establishing lifelong latency in rodents. While many studies have demonstrated the ability of this viral infection to modulate immune responses, a unifying mechanism for HV-68-induced subversion of a protective host response remains elusive. We questioned whether infection with HV-68 could expand a population of myeloid derived suppressor cells (MDSC) as one mechanism for altering protective immunity. Mice… CONTINUE READING
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