Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation.

@article{Hayakawa2000MurineFR,
  title={Murine fetal resorption and experimental pre-eclampsia are induced by both excessive Th1 and Th2 activation.},
  author={Satoshi Hayakawa and Takahiko Fujikawa and Hayato Fukuoka and Fumihisa Chisima and Miki Karasaki-Suzuki and Emika Ohkoshi and Hiroyuki Ohi and T Kiyoshi Fujii and Mamoru Tochigi and Kumi Satoh and Takahiro Shimizu and Susumu Nishinarita and Nobuo Nemoto and Isamu Sakurai},
  journal={Journal of reproductive immunology},
  year={2000},
  volume={47 2},
  pages={121-38}
}
It has been proposed that immune responses in mammalian normal pregnancy are Th2-like, thereby protecting the fetus and placenta from being rejected. Administration of exogenous Th1 cytokines into pregnant mice is reported to induce feto-placental resorption. However, the effects of exogenous Th2 cytokines and Th2 directed responses in pregnant animals have not been well studied. In this study, we examined IL-4 and IL-12, which play decisive roles in the development of Th2 and Th1 responses… CONTINUE READING