Murine experimental abortion by IL-2 administration is caused by activation of cytotoxic T lymphocytes and placental apoptosis.

@article{Shiraishi1996MurineEA,
  title={Murine experimental abortion by IL-2 administration is caused by activation of cytotoxic T lymphocytes and placental apoptosis.},
  author={Hidemori Shiraishi and Satoshi Hayakawa and Kei Satoh},
  journal={Journal of clinical & laboratory immunology},
  year={1996},
  volume={48 3},
  pages={93-108}
}
OBJECTIVE Fetal loss caused by IL-2 administration to pregnant mice is regarded as a model of human habitual abortion due to allo-immune reactions. To estimate feto-placental damages in this model, we examined apoptosis histochemically in the placenta. METHODS Four allogenic mated mice were administered intraperitoneally with 1000 IU of recombinant human IL-2 on days 3, 5 (7) after mating. We examined the presence of apoptosis in the placentae by TUNEL stain. We also examined expression of… CONTINUE READING