Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded-protein response.

@article{Qian2012MurineCT,
  title={Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded-protein response.},
  author={Zhikang Qian and Baoqin Xuan and Travis J. Chapa and Nathaniel C. Gualberto and Dong Liang Yu},
  journal={Journal of virology},
  year={2012},
  volume={86 12},
  pages={6712-23}
}
The unfolded-protein response (UPR), activated by sensor molecules PERK, ATF6, and IRE1 to resolve endoplasmic reticulum (ER) stress, has emerged as a key target for host cells and viruses to control the infection outcomes. The UPR regulates ER protein folding, controls cell fate upon ER stress, and plays an important role in innate immunity. We and others have shown that human cytomegalovirus (HCMV) modulates the UPR. We show here that murine CMV (MCMV), the widely used CMV model for small… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS