Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells.

@article{Voigt2003MurineCM,
  title={Murine cytomegalovirus m157 mutation and variation leads to immune evasion of natural killer cells.},
  author={Valentina Voigt and Catherine A. Forbes and Joanne N Tonkin and Mariapia A Degli-Esposti and Hamish R. C. Smith and Wayne M Yokoyama and Anthony A. Scalzo},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100 23},
  pages={13483-8}
}
Effective natural killer (NK) cell recognition of murine cytomegalovirus (MCMV)-infected cells depends on binding of the Ly49H NK cell activation receptor to the m157 viral glycoprotein. Here we addressed the immunological consequences of variation in m157 sequence and function. We found that most strains of MCMV possess forms of m157 that evade Ly49H-dependent NK cell activation. Importantly, repeated passage of MCMV through resistant Ly49H+ mice resulted in the rapid emergence of m157 mutants… CONTINUE READING

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