Murine cytomegalovirus infection alters Th1/Th2 cytokine expression, decreases airway eosinophilia, and enhances mucus production in allergic airway disease.

@article{Wu2001MurineCI,
  title={Murine cytomegalovirus infection alters Th1/Th2 cytokine expression, decreases airway eosinophilia, and enhances mucus production in allergic airway disease.},
  author={Carol A Wu and Lynn Puddington and Herbert E. Whiteley and C A Yiamouyiannis and Craig M. Schramm and F Mohammadu and Roger S. Thrall},
  journal={Journal of immunology},
  year={2001},
  volume={167 5},
  pages={2798-807}
}
Concomitant infection of murine CMV (MCMV), an opportunistic respiratory pathogen, altered Th1/Th2 cytokine expression, decreased bronchoalveolar lavage (BAL) fluid eosinophilia, and increased mucus production in a murine model of OVA-induced allergic airway disease. Although no change in the total number of leukocytes infiltrating the lung was observed between challenged and MCMV/challenged mice, the cellular profile differed dramatically. After 10 days of OVA-aerosol challenge, eosinophils… CONTINUE READING

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