Murine cytomegalovirus immediate-early promoter directs astrocyte-specific expression in transgenic mice.

@article{AibaMasago1999MurineCI,
  title={Murine cytomegalovirus immediate-early promoter directs astrocyte-specific expression in transgenic mice.},
  author={Sonomi Aiba-Masago and S. El Baba and Rita Y Li and Yuichiro Shinmura and Isao Kosugi and Yoshifumi Arai and Mayumi Nishimura and Yoshihiro Tsutsui},
  journal={The American journal of pathology},
  year={1999},
  volume={154 3},
  pages={735-43}
}
Murine cytomegalovirus (MCMV), which causes acute, latent, and persistent infection of the natural host, is used as an animal model of human cytomegalovirus (HCMV) infection. Transcription of MCMV immediate-early (IE) genes is required for expression of the early and late genes and is dependent on host cell transcription factors. Cell-type-specific expression activity of the MCMV IE promoter was analyzed in transgenic mice generated with the major IE (MIE) enhancer/promoter involving… CONTINUE READING