Murine coronavirus membrane fusion is blocked by modification of thiols buried within the spike protein.

@article{Gallagher1996MurineCM,
  title={Murine coronavirus membrane fusion is blocked by modification of thiols buried within the spike protein.},
  author={Thomas M. Gallagher},
  journal={Journal of virology},
  year={1996},
  volume={70 7},
  pages={4683-90}
}
The envelopes of murine hepatitis virus (MHV) particles are studded with glycoprotein spikes that function both to promote virion binding to its cellular receptor and to mediate virion-cell membrane fusion. In this study, the cysteine-rich spikes were subjected to chemical modification to determine whether such structural alterations impact the virus entry process. Ellman reagent, a membrane-impermeant oxidizing agent which reacts with exposed cysteine residues to effect covalent addition of… CONTINUE READING
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