Murine collagen antibody induced arthritis (CAIA) and primary mouse hepatocyte culture as models to study cytochrome P450 suppression.

@article{Dickmann2012MurineCA,
  title={Murine collagen antibody induced arthritis (CAIA) and primary mouse hepatocyte culture as models to study cytochrome P450 suppression.},
  author={Leslie J. Dickmann and Helen J McBride and Sonal K Patel and Kent Miner and Larry C. Wienkers and John G. Slatter},
  journal={Biochemical pharmacology},
  year={2012},
  volume={83 12},
  pages={1682-9}
}
Changes in cytochrome P450 expression incurred by inflammatory disease were studied in a murine collagen antibody induced arthritis (CAIA) model and compared to bacterial lipopolysaccharide-treated mice and to cytochrome P450 changes in primary mouse hepatocytes following combination treatments with cytokines IL-1β, IL-6, or TNFα. CAIA in female mice increased serum IL-1β, IL-6 and hepatic serum amyloid A (SAA) mRNA and significantly altered cytochrome P450 mRNA and activity levels. Most… CONTINUE READING