Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine.

@article{Cabrales2010MurineCM,
  title={Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine.},
  author={Pedro J. Cabrales and Graziela Maria Zanini and Diana R. Meays and John A. Frangos and Leonardo Jos{\'e} de Moura Carvalho},
  journal={The American journal of pathology},
  year={2010},
  volume={176 3},
  pages={1306-15}
}
Brain hemodynamics in cerebral malaria (CM) is poorly understood, with apparently conflicting data showing microcirculatory hypoperfusion and normal or even increased blood flow in large arteries. Using intravital microscopy to assess the pial microvasculature through a closed cranial window in the murine model of CM by Plasmodium berghei ANKA, we show that murine CM is associated with marked decreases (mean: 60%) of pial arteriolar blood flow attributable to vasoconstriction and decreased… CONTINUE READING
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