Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration.

@article{Tuo2007MurineCD,
  title={Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration.},
  author={Jingsheng Tuo and Christine M. Bojanowski and Min Zhou and Defen Shen and Robert J. Ross and Kevin I. Rosenberg and D. Joshua Cameron and Chunyue Yin and Jeffrey A. Kowalak and Zhengping Zhuang and Kang Zhang and Chi-Chao Chan},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 8},
  pages={
          3827-36
        }
}
PURPOSE Senescent Ccl2(-/-) mice are reported to develop cardinal features of human age-related macular degeneration (AMD). Loss-of-function single-nucleotide polymorphisms within CX3CR1 are also found to be associated with AMD. The authors generated Ccl2(-/-)/Cx3cr1(-/-) mice to establish a more characteristic and reproducible AMD model. METHODS Single Ccl2- and Cx3cr1-deficient mice were crossbred to obtain Ccl2(-/-)/Cx3cr1(-/-) mice. Funduscopy, histopathology, retinal A2E quantification… CONTINUE READING

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