Murine bladder carcinoma cells present antigen to BCG-specific CD4+ T-cells.

@article{Lattime1992MurineBC,
  title={Murine bladder carcinoma cells present antigen to BCG-specific CD4+ T-cells.},
  author={Edmund C. Lattime and Leonard G. Gomella and Peter A. McCue},
  journal={Cancer research},
  year={1992},
  volume={52 15},
  pages={4286-90}
}
Intravesical administration of Bacillus Calmette-Guérin (BCG) is the most effective therapy for superficial transitional cell carcinoma of the bladder although its mechanism of action is not known. To determine if bladder tumors are capable of antigen presentation and thus might interact directly with BCG-specific T-cells, we studied the murine bladder tumor MB49. MB49 (MHC Class II negative) (IA-), when induced to express IA with interferon, presented BCG to specific CD4+ T-cells obtained from… CONTINUE READING
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