Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification.

@article{MacPherson2007MurineBR,
  title={Murine bilateral retinoblastoma exhibiting rapid-onset, metastatic progression and N-myc gene amplification.},
  author={David MacPherson and Karina Conkrite and Mandy Chi-Mun Tam and Shizuo Mukai and David Mu and Tyler 8 Jacks},
  journal={The EMBO journal},
  year={2007},
  volume={26 3},
  pages={
          784-94
        }
}
Human retinoblastoma is a pediatric cancer initiated by RB gene mutations in the developing retina. We have examined the origins and progression of retinoblastoma in mouse models of the disease. Retina-specific inactivation of Rb on a p130-/- genetic background led to bilateral retinoblastoma with rapid kinetics, whereas on a p107-/- background Rb mutation caused predominantly unilateral tumors that arose with delayed kinetics and incomplete penetrance. In both models, retinoblastomas arose… CONTINUE READING
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