Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells.

@article{Ophir2013MurineAC,
  title={Murine anti-third-party central-memory CD8(+) T cells promote hematopoietic chimerism under mild conditioning: lymph-node sequestration and deletion of anti-donor T cells.},
  author={Eran Ophir and Noga Or-Geva and Irina Gurevich and Orna Tal and Yaki Eidelstein and Elias Shezen and Raanan Margalit and Assaf Lask and Guy Shakhar and David Hagin and Esther Bachar-Lustig and Shlomit Reich-Zeliger and Andreas Beilhack and Robert S. Negrin and Yair Reisner},
  journal={Blood},
  year={2013},
  volume={121 7},
  pages={
          1220-8
        }
}
Transplantation of T cell-depleted BM (TDBM) under mild conditioning, associated with minimal toxicity and reduced risk of GVHD, offers an attractive therapeutic option for patients with nonmalignant hematologic disorders and can mediate immune tolerance to subsequent organ transplantation. However, overcoming TDBM rejection after reduced conditioning remains a challenge. Here, we address this barrier using donorderived central memory CD8(+) T cells (Tcms), directed against third-party antigens… CONTINUE READING
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