Murine adenovirus infection of SCID mice induces hepatic lesions that resemble human Reye syndrome.

@article{Pirofski1991MurineAI,
  title={Murine adenovirus infection of SCID mice induces hepatic lesions that resemble human Reye syndrome.},
  author={Liise-anne Pirofski and Marshall S Horwitz and Matthew D. Scharff and S M Factor},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1991},
  volume={88 10},
  pages={4358-62}
}
Murine adenovirus type 1 (MAV-1) infection of CB-17 SCID mice (which are homozygous for the severe combined immunodeficiency mutation) induces hepatic histopathologic and ultrastructural features that are strikingly similar to human Reye syndrome. Gross pathologic examination of MAV-1-infected mice revealed only pale yellow liver tissue. Histopathologic studies of tissue from MAV-1-infected mice revealed diffuse hepatic injury manifested by microvesicular fatty degenerative changes of… CONTINUE READING