• Biology, Medicine
  • Published in Haematologica 2005

Murine acute promyelocytic leukemia cells can be recognized and cleared in vivo by adaptive immune mechanisms.

@article{Pollock2005MurineAP,
  title={Murine acute promyelocytic leukemia cells can be recognized and cleared in vivo by adaptive immune mechanisms.},
  author={Jessica L. Pollock and Andrew A. Lane and Kelly Schrimpf and Timothy J. Ley},
  journal={Haematologica},
  year={2005},
  volume={90 8},
  pages={
          1042-9
        }
}
BACKGROUND AND OBJECTIVES In this study, we tested whether transgenic murine acute promyelocytic leukemia (APL) cells can be recognized and cleared by adaptive immune responses and/or vaccination strategies. DESIGN AND METHODS Immunocompetent and SCID mice were examined for their ability to survive a challenge of APL cells. We also vaccinated immunocompetent mice with DNA vaccines encoding various portions of a bcr-1 PML-RARa fusion protein. RESULTS In genetically compatible… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 32 REFERENCES