Murine V lambda x and V lambda x-containing antibodies bind human myelin basic protein.

@article{Galin1996MurineVL,
  title={Murine V lambda x and V lambda x-containing antibodies bind human myelin basic protein.},
  author={F. Shawn Galin and Curtis C. Maier and Shou Zhou and John N. Whitaker and Jeana E. Blalock},
  journal={The Journal of clinical investigation},
  year={1996},
  volume={97 2},
  pages={486-92}
}
Myelin basic protein (MBP) is highly immunogenic and a known autoantigen capable of inducing experimental allergic encephalomyelitis (EAE), the animal model of multiple sclerosis. We have previously described a murine monoclonal antibody (mAb), F28C4, directed against the encephalitogenic MBP peptide acetyl (Ac) 1-9, which contains a V lambda x light chain. Considering the rarity of V lambda x usage, we determined whether other Abs having V lambda x light chains shared similar antigen (Ag… CONTINUE READING

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