Murine Transporter Associated with Antigen Presentation (TAP) Preferences Influence Class I–restricted T Cell Responses

@article{YellenShaw1997MurineTA,
  title={Murine Transporter Associated with Antigen Presentation  (TAP) Preferences Influence Class I–restricted T Cell Responses },
  author={Amy J. Yellen-Shaw and Carol E. Laughlin and Robert M. Metrione and Laurence Eisenlohr},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={1655 - 1662}
}
The transporter associated with antigen presentation (TAP) complex shuttles cytosolic peptides into the exocytic compartment for association with nascent major histocompatibility complex class I molecules. Biochemical studies of murine and human TAP have established that substrate length and COOH-terminal residue identity are strong determinants of… CONTINUE READING