Murine TOLL-like Receptor 4 Confers Lipopolysaccharide Responsiveness as Determined by Activation of NFκB and Expression of the Inducible Cyclooxygenase*

  title={Murine TOLL-like Receptor 4 Confers Lipopolysaccharide Responsiveness as Determined by Activation of NF$\kappa$B and Expression of the Inducible Cyclooxygenase*},
  author={Sang Hoon Rhee and Daniel Hwang},
  journal={The Journal of Biological Chemistry},
  pages={34035 - 34040}
  • S. RheeD. Hwang
  • Published 3 November 2000
  • Biology
  • The Journal of Biological Chemistry
Genetic evidence indicating that TOLL-like receptor 4 (Tlr4) is the lipopolysaccharide (LPS) receptor in mice was reported. However, biochemical evidence that murine Tlr4 confers LPS responsiveness has not been convincingly demonstrated. Inducible cyclooxygenase (COX-2) is selectively expressed in LPS-stimulated macrophages in part mediated through the activation of NFκB. Thus, we determined whether murine Tlr4 confers LPS responsiveness as evaluated by the activation of NFκB and COX-2… 

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