Murine Sall1 represses transcription by recruiting a histone deacetylase complex.

  title={Murine Sall1 represses transcription by recruiting a histone deacetylase complex.},
  author={Susan McLeskey Kiefer and Bradley W McDill and Jing Yang and Michael Rauchman},
  journal={The Journal of biological chemistry},
  volume={277 17},
The multi-zinc finger proteins of the Sal family regulate organogenesis. Genetic evidence from Drosophila has shown that spalt (sal) can alter gene expression in a cell autonomous fashion, but Sal proteins have never been directly analyzed for their ability to activate or repress transcription. In this report, we show that a member of the Sal family, mouse Sall1, is a potent transcriptional repressor. When fused to a heterologous DNA-binding domain, Sall1 represses transcription of a luciferase… CONTINUE READING


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