Murine SPAM1 is secreted by the estrous uterus and oviduct in a form that can bind to sperm during capacitation: acquisition enhances hyaluronic acid-binding ability and cumulus dispersal efficiency.

@article{Griffiths2008MurineSI,
  title={Murine SPAM1 is secreted by the estrous uterus and oviduct in a form that can bind to sperm during capacitation: acquisition enhances hyaluronic acid-binding ability and cumulus dispersal efficiency.},
  author={Genevieve S Griffiths and Kimberly A. Clausing Thormund A. Miller and Deni S Galileo and Patricia A Martin-DeLeon},
  journal={Reproduction},
  year={2008},
  volume={135 3},
  pages={293-301}
}
Sperm uptake of epididymal sperm adhesion molecule 1 (SPAM1) in vitro has recently been shown to be a marker of sperm maturation, since acquisition of this surface hyaluronidase increases cumulus dispersal efficiency. Here, we demonstrate that this glycosyl phosphatidylinositol-linked sperm antigen, previously shown to be expressed during estrous in the female reproductive tract, is secreted in the uterine and oviductal fluids (ULF and OF respectively) in a 67 kDa form, which can bind to sperm… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 39 references

The dual functions of GPI-anchored PH-20: hyaluronidase and intracellular signaling.

Matrix biology : journal of the International Society for Matrix Biology • 2001
View 5 Excerpts
Highly Influenced

Epididymal SPAM1 and its impact on sperm function.

Molecular and cellular endocrinology • 2006
View 5 Excerpts

Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 1 Excerpt

Similar Papers

Loading similar papers…